Krasavage W J, O'Donoghue J L
Drug Chem Toxicol. 1984;7(4):335-43. doi: 10.3109/01480548408998262.
Tertiary butylhydroquinone (TBHQ), a phenolic antioxidant used in foods, was tested for its potential to produce lung damage in mice similar to that seen following administration of butylated hydroxytoluene (BHT). Male mice (CRL:CD-1) were given single intraperitoneal injections of 62.5, 125, 250 or 500 mg/kg TBHQ or 300, 625 or 1230 mg/kg BHT in corn oil. Survivors were killed five days after treatment and the lungs were removed, weighed, and processed for histologic examination. Lung weights of the TBHQ treated animals were comparable to the controls, while BHT produced a statistically significant increase in lung weight. Histologically, BHT produced hyperplasia of pulmonary pneumocytes as previously reported. No treatment-related lung lesions were seen in the TBHQ mice. The results of this study indicate that TBHQ does not produce pulmonary lesions in mice.
叔丁基对苯二酚（TBHQ）是一种用于食品的酚类抗氧化剂，我们对其在小鼠中产生肺部损伤的可能性进行了测试，该损伤类似于给予丁基羟基甲苯（BHT）后所观察到的情况。雄性小鼠（CRL:CD-1）通过腹腔单次注射给予62.5、125、250或500mg/kg的TBHQ或300、625或1230mg/kg的BHT（溶于玉米油中）。治疗五天后处死存活的小鼠，取出肺脏，称重，并进行组织学检查。接受TBHQ治疗的动物的肺重量与对照组相当，而BHT导致肺重量出现统计学上的显著增加。组织学上，BHT如先前报道的那样导致肺上皮细胞增生。在接受TBHQ治疗的小鼠中未观察到与治疗相关的肺部病变。这项研究的结果表明，TBHQ不会在小鼠中产生肺部病变。
