Engelhardt G H
Fortschr Med. 1978 Apr 27;96(16):851-7.
Burn disease is a severe complication of all extensive deep burns. Therefore, the destroyed skin must be removed and the open wounds closed as soon as possible. Until now only the early surgical necrectomy and grafting can meet these essentials. Our studies on "chemical débridement" by various enzyme preparations showed that collagenase hastened the removal of dead tissue without any complications. The subsequent application of soluble collagen to the would area caused significant acceleration of wound closure in rats as well as in pigs without immunological reactions. Finally, evidence of anti-collagen antibodies may be important for the treatment of burn disease if a direct effect can be proved.
烧伤病是所有大面积深度烧伤的严重并发症。因此，必须尽快切除坏死皮肤并封闭开放性伤口。到目前为止，只有早期手术切除坏死组织并进行植皮才能满足这些要求。我们对各种酶制剂进行“化学清创”的研究表明，胶原酶能加速坏死组织的清除且无任何并发症。随后在伤口部位应用可溶性胶原，在大鼠和猪身上均显著加速了伤口愈合，且无免疫反应。最后，如果能证明有直接作用，抗胶原抗体的证据对于烧伤病的治疗可能很重要。
