Carandente F, Halberg E, Halberg F
Fortschr Med. 1978 May 11;96(18):983-8.
Against the background of clinical experience attesting to the role of the circadian and circannual rhythm stage in gastric ulcerogenesis, animal experiments provide a model where by circadian stage and sex are both revealed as determinants of gastric ulcerogenesis. Experiments on the genetically mesor-hypertensive Okamoto rat demonstrate the critical interaction of multiple loads in ulcerogenesis, in keeping with a report by Glavin and Mikhail. While stimulation by single loads of a certain intensity--immobilization, food deprivation or cooling--did not regularly lead to the production of gastric ulcers, the combination of these same loads did so as a function of circadian state at the beginning of exposure time.
在临床经验证实昼夜节律和年节律阶段在胃溃疡形成中起作用的背景下，动物实验提供了一个模型，通过该模型揭示了昼夜节律阶段和性别都是胃溃疡形成的决定因素。对遗传性中高血压冈本大鼠的实验表明，在溃疡形成过程中多种负荷存在关键相互作用，这与格拉文和米哈伊尔的报告一致。虽然单一强度负荷（固定、禁食或冷却）的刺激通常不会导致胃溃疡的产生，但这些相同负荷的组合却会根据暴露时间开始时的昼夜节律状态导致胃溃疡的产生。
