Henning D S, Lajoie G A, Brown G R, St-Pierre L E, St-Pierre S
Int J Artif Organs. 1984 Jul;7(4):209-14.
Merrifield resins with various amino acid containing pendants and a water swellable polyamide resin with the peptide alanine-alanine-alanine-arginine as the pendant group have been prepared by solid phase peptide synthesis. Merrifield resins with either arginine or lysine pendants are capable of sorbing bilirubin from aqueous solution (pH = 7.8) but those with other amino acid pendants gave no indication of sorption. The polyamide-arginine resin showed, on a functional group basis, a higher capacity for bilirubin than does cholestyramine. It is proposed that the formation of salt linkages causes a strong interaction of bilirubin with arginine and lysine.
通过固相肽合成法制备了带有各种含氨基酸侧链的 Merrifield 树脂以及一种以肽丙氨酸 - 丙氨酸 - 丙氨酸 - 精氨酸为侧链基团的水溶胀聚酰胺树脂。带有精氨酸或赖氨酸侧链的 Merrifield 树脂能够从水溶液（pH = 7.8）中吸附胆红素，但带有其他氨基酸侧链的树脂未显示出吸附迹象。基于官能团，聚酰胺 - 精氨酸树脂对胆红素的吸附能力高于消胆胺。有人提出盐键的形成导致胆红素与精氨酸和赖氨酸之间产生强烈相互作用。
