Zhu X X, Brown G R, St-Pierre L E
Department of Chemistry, McGill University, Montreal, PQ, Canada.
Biomater Artif Cells Artif Organs. 1990;18(1):75-93. doi: 10.3109/10731199009117290.
Poly-L-lysine, poly-D-lysine and poly-L-ornithine have been coated covalently onto a water-swellable polyamide resin. These sorbents, especially the polylysine coated resins, exhibit high binding affinities for bilirubin in aqueous phosphate buffer solutions at 0 degrees C. The polylysine coated resins have an improved binding affinity for bilirubin over the sorbents with lysine containing oligopeptide pendants and much higher affinity than cholestyramine. The binding capacity is directly proportional to the number of lysine residues on the resin. Replacement of poly-L-lysine with poly-D-lysine does not affect the adsorption capacity.
聚-L-赖氨酸、聚-D-赖氨酸和聚-L-鸟氨酸已共价包被在一种水溶胀性聚酰胺树脂上。这些吸附剂，尤其是聚赖氨酸包被的树脂，在0℃的磷酸盐水溶液中对胆红素表现出高结合亲和力。聚赖氨酸包被的树脂对胆红素的结合亲和力比含有赖氨酸的寡肽侧链的吸附剂有所提高，且比消胆胺的亲和力高得多。结合容量与树脂上赖氨酸残基的数量成正比。用聚-D-赖氨酸替代聚-L-赖氨酸不会影响吸附容量。
