Henning D S, Brown G R, St-Pierre L E
Int J Artif Organs. 1986 Jan;9(1):33-8.
Short peptides, three to eight amino acids in length, containing various combinations of alanine, arginine, lysine, histidine and tyrosine have been synthesized onto water-swellable polyamide resin by the solid phase peptide synthesis method. The amount of bilirubin adsorbed from aqueous buffer solution (pH = 7.8) by the resins increases with increasing basicity of the amino acids in the pendant. As the number of basic amino acids on the pendant is increased from one to five a 4.7 fold enhancement in the adsorption capacity is seen for arginine while a 9.3 fold enhancement is obtained for lysine. A corresponding increase in length for the non-basic histidine results in a 6 fold enhancement. With alanine the adsorption capacity is uneffected by an increase in pendant length.
通过固相肽合成方法，已将长度为三至八个氨基酸、包含丙氨酸、精氨酸、赖氨酸、组氨酸和酪氨酸各种组合的短肽合成到水溶胀性聚酰胺树脂上。这些树脂从缓冲水溶液（pH = 7.8）中吸附的胆红素量随着侧链氨基酸碱性的增加而增加。当侧链上碱性氨基酸的数量从一个增加到五个时，精氨酸的吸附容量提高了4.7倍，而赖氨酸则提高了9.3倍。非碱性组氨酸侧链长度的相应增加导致吸附容量提高了6倍。对于丙氨酸，吸附容量不受侧链长度增加的影响。
