Bertók L, Juhász-Nagy A, Sótonyi P
Immunopharmacology. 1984 Aug;8(1):13-7. doi: 10.1016/0162-3109(84)90052-3.
Radio-detoxified endotoxin (Tolerin), produced by 60Co-gamma irradiation of Escherichia coli 089 endotoxin, can protect dogs against the acute cardiotoxic side-effects of formyl-leurosine, a semi-synthetic Vinca derivative with promising antineoplastic potency. Formyl-leurosine induces a rapid decrease in arterial blood pressure and diminishes the contractile force of the myocardium in the anaesthetized dog. These responses indicate a direct pharmacologic relaxant effect of the drug on the heart and vasculature smooth muscle. The early cardiovascular depression is of short duration and is unaffected by Tolerin. Tolerin can prevent, however, the secondary, more dangerous phase of circulatory depression that is associated with the severe cardiotoxic manifestations of the drug, as demonstrated by hemodynamic and morphologic (light and electronmicroscopic) patterns.
经60Co-γ射线辐照大肠杆菌089内毒素产生的放射性解毒内毒素（托勒林），可保护犬类免受甲酰长春胺的急性心脏毒性副作用，甲酰长春胺是一种具有潜在抗肿瘤效力的半合成长春花衍生物。甲酰长春胺可使麻醉犬的动脉血压迅速下降，并减弱心肌收缩力。这些反应表明该药物对心脏和血管平滑肌具有直接的药理松弛作用。早期的心血管抑制持续时间较短，且不受托勒林影响。然而，血流动力学和形态学（光学和电子显微镜）模式显示，托勒林可预防与该药物严重心脏毒性表现相关的继发性、更危险的循环抑制阶段。
