Balogh A, Furka I, Sótonyi P, Dalmy L, Bertók L
Z Exp Chir. 1981;14(3):156-64.
An acute myocardial infarction was produced in experiments in dogs by ligature of the ramus anterior of the left coronary artery. Cell damages in the liver showed electron microscopically 90 and 120 minutes after the begin of the experiment. Destruction or disturbance in the permeability of the liver cells was not or slight developed by pretreatment with radiologically detoxicated endotoxin. In this case no aggravation of the liver function was evident parallel to the morphological changes and the ability of the liver to detoxication of endotoxin was reserved. The experiment shows that the protective effect of Tolerin which prevented the ischemic liver cell damage is not the endotoxin tolerance. The stabilizing effect to the lysosomal membrane by Tolerin is the cause likely.
通过结扎犬左冠状动脉前支在实验中制造急性心肌梗死。实验开始后90分钟和120分钟，肝脏细胞损伤通过电子显微镜观察。用放射解毒的内毒素预处理后，肝细胞通透性的破坏或紊乱未出现或仅轻微发展。在这种情况下，肝功能并未随着形态学变化而明显恶化，肝脏对内毒素的解毒能力得以保留。实验表明，托乐林预防缺血性肝细胞损伤的保护作用并非内毒素耐受性。托乐林对溶酶体膜的稳定作用可能是原因所在。
