[Protective effect on the liver through premedication with radiologically detoxicated endotoxin (Tolerin) in acute myocardial infarction in dogs].

An acute myocardial infarction was produced in experiments in dogs by ligature of the ramus anterior of the left coronary artery. Cell damages in the liver showed electron microscopically 90 and 120 minutes after the begin of the experiment. Destruction or disturbance in the permeability of the liver cells was not or slight developed by pretreatment with radiologically detoxicated endotoxin. In this case no aggravation of the liver function was evident parallel to the morphological changes and the ability of the liver to detoxication of endotoxin was reserved. The experiment shows that the protective effect of Tolerin which prevented the ischemic liver cell damage is not the endotoxin tolerance. The stabilizing effect to the lysosomal membrane by Tolerin is the cause likely.