Dunlop D S, Kaufman H, Zanchin G, Lajtha A
J Neurochem. 1984 Nov;43(5):1487-9. doi: 10.1111/j.1471-4159.1984.tb05413.x.
Protein synthesis rates were measured (33 days postoperatively) in rats with portacaval shunts and in unoperated controls. In brain, no change in the rate of protein synthesis was evident in shunted rats. These data thus do not support the hypothesis that an inhibition of brain protein synthesis is a factor in the etiology of hepatic encephalopathy. The synthesis rate in forebrain at 82 days of age was 0.52%/h. Though brain wet weight was the same in both groups, rats with shunts grew relatively slowly, and their testicles probably decreased in weight. However, no inhibition of muscle, liver, or testicular protein synthesis could be detected. The mechanism of slower or negative growth in these tissues might thus involve an increase in the degradation rate, although a transient inhibition of synthesis at an earlier period is also possible.
在接受门腔分流术的大鼠和未手术的对照大鼠中测量了（术后33天）蛋白质合成速率。在大脑中，分流大鼠的蛋白质合成速率没有明显变化。因此，这些数据不支持脑蛋白质合成抑制是肝性脑病病因学中的一个因素这一假说。82日龄时前脑的合成速率为0.52%/小时。尽管两组大鼠的脑湿重相同，但分流大鼠生长相对缓慢，其睾丸重量可能减轻。然而，未检测到肌肉、肝脏或睾丸蛋白质合成受到抑制。因此，这些组织生长缓慢或负增长的机制可能涉及降解速率的增加，尽管在早期也可能存在合成的短暂抑制。
