Stolley P D, Soper K A, Galloway S M, Nichols W W, Norman S A, Wolman S R
Mutat Res. 1984 Oct;129(1):89-102. doi: 10.1016/0027-5107(84)90127-1.
Sister-chromatid exchange (SCE) frequencies in employees potentially exposed to ethylene oxide (ETO) were compared with those in unexposed control groups. Three worksites where the previous environmental control of ETO was known to have differed were chosen. Within these worksites, subjects were categorized into high potential exposed, low potential exposed and control groups. An additional community control group was obtained. Blood samples for chromosome studies of peripheral lymphocytes were drawn at several time points over a period of 24 months. The effects on SCE of age, sex, smoking habits and reader variation were considered. Worksites I, II and III, respectively, represented increasing levels of exposure. At Worksite III large differences among groups persisted over 24 months. At Worksite II, the SCEs in the high potential exposed workers were higher than those in the other groups. At no time was the low potential exposed group at Worksite II statistically significantly higher in mean SCE than the worksite controls. No consistent differences among groups were noted in Worksite I.
将可能接触环氧乙烷（ETO）的员工的姐妹染色单体交换（SCE）频率与未接触的对照组进行比较。选择了三个已知先前环氧乙烷环境控制情况不同的工作场所。在这些工作场所内，将受试者分为高潜在暴露组、低潜在暴露组和对照组。另外还设立了一个社区对照组。在24个月的时间段内的几个时间点采集外周淋巴细胞染色体研究的血样。考虑了年龄、性别、吸烟习惯和阅片者差异对SCE的影响。工作场所I、II和III分别代表暴露水平的增加。在工作场所III，各组之间的巨大差异在24个月内持续存在。在工作场所II，高潜在暴露工人的SCE高于其他组。在工作场所II，低潜在暴露组的平均SCE在任何时候都没有在统计学上显著高于工作场所对照组。在工作场所I，未观察到各组之间的一致差异。
