Partanen M, Linnoila I, Hervonent A, Rapoport S I
Neurobiol Aging. 1984 Summer;5(2):105-10. doi: 10.1016/0197-4580(84)90039-3.
Cell number and catecholamine histofluorescence were determined in three extra-adrenal chromaffin tissues: the abdominal paraganglia, the carotid body and SIF (small intensely fluorescent)-cells, of male Fischer-344 rats at different ages. Catecholamines were demonstrated using the formaldehyde-induced fluorescence method. The number of paraganglia cells in the retroperitoneal area increased 13.6 fold between 3 and 33 months of age, and the volume of abdominal paraganglia approached 65% of the volume of one adrenal medulla. The emission color of some paraganglia cells shifted from greenish-yellow to yellowish-brown with aging, but differences were not observed in cell number of fluorophore color in the carotid body, a chemoreceptor type of paraganglion. The number of SIF cells (an intraganglionic variant of extra-adrenal chromaffin tissue) in the hypogastric ganglion increased significantly between 3 and 33 months. The pronounced increase of the volume of the paraganglia in aged rats may contribute to elevated concentrations of circulating catecholamines in these animals.
在不同年龄的雄性Fischer-344大鼠的三种肾上腺外嗜铬组织（腹主动脉旁神经节、颈动脉体和SIF（小而强荧光）细胞）中测定了细胞数量和儿茶酚胺组织荧光。使用甲醛诱导荧光法显示儿茶酚胺。腹膜后区域的副神经节细胞数量在3至33个月龄之间增加了13.6倍，腹主动脉旁神经节的体积接近一个肾上腺髓质体积的65%。随着年龄增长，一些副神经节细胞的发射颜色从绿黄色变为黄褐色，但在作为化学感受器类型副神经节的颈动脉体中，细胞数量或荧光团颜色未观察到差异。在3至33个月之间，腹下神经节中SIF细胞（肾上腺外嗜铬组织的神经节内变体）的数量显著增加。老年大鼠副神经节体积的显著增加可能导致这些动物循环儿茶酚胺浓度升高。
