Sander J, Bay D, Gedde-Dahl T W, Borchgrevink H M, Frøholm L O, Oftedal S I, Vandvik B
NIPH Ann. 1984 Jun;7(1):3-11.
The occurrence of sequelae 3-15 years after meningococcal disease has been investigated in a study on 71 patients and 64 controls. The patients were young men, aged 18 to 24 years at the time the disease was contracted. Participants filled in a questionnaire on possible symptoms. Audiometry and EEG were also carried out. The response rates were 84% among patients and 75% among controls. We found that 61% of the patients had one or more symptoms of possible sequelae compared to 20% in the control group (p less than 0.001). The symptoms were generally light and of mental or neurological type. Among the patients 13% stated that they had obvious complaints commonly attributed to meningococcal disease, compared to 2% only in the controls (p less than 0.05). Twenty-nine per cent of the patients stated that the disease had affected their education or working capacity. No statistical differences between patients and controls were demonstrated by audiological or EEG examinations. In only one single ear could deafness unequivocally be attributed to the disease.
一项针对71例患者和64名对照者的研究，调查了脑膜炎球菌病发生3至15年后的后遗症情况。这些患者均为青年男性，患病时年龄在18至24岁之间。参与者填写了一份关于可能症状的问卷。同时还进行了听力测定和脑电图检查。患者的应答率为84%，对照者的应答率为75%。我们发现，61%的患者有一项或多项可能的后遗症症状，而对照组这一比例为20%（p值小于0.001）。这些症状通常较轻，属于精神或神经类型。在患者中，13%表示他们有通常归因于脑膜炎球菌病的明显不适，而对照组仅为2%（p值小于0.05）。29%的患者表示该病影响了他们的教育或工作能力。听力测定或脑电图检查未显示患者与对照者之间存在统计学差异。只有一只耳朵的耳聋可明确归因于该病。
