胎儿及成人大脑中胆碱乙酰转移酶（ChAT）活性的偏侧化

Lateralization of choline acetyltransferase (ChAT) activity in fetus and adult human brain.

作者信息

Bracco L, Tiezzi A, Ginanneschi A, Campanella C, Amaducci L

出版信息

Neurosci Lett. 1984 Sep 7;50(1-3):301-5. doi: 10.1016/0304-3940(84)90503-2.

Abstract

Choline acetyltransferase (ChAT) activity was measured in the first temporal gyrus (Brodmann area 22) and in the gyrus precentrale (Brodmann area 4) of both hemispheres in post-mortem human fetus and adult brains. In fetal brains the ChAT values were higher in the right first temporal gyrus in comparison to the left one (P less than 0.05). Conversely in adult brains ChAT activity was higher in the left first temporal gyrus than in the controlateral one (P less than 0.05). Absolute values of ChAT were similar in the right first temporal gyrus of fetus and adult brains. No asymmetry was found in the fetal and adult gyrus precentrale. These findings could be interpreted in terms of differential rates of development of cholinergic synapses in left and right human temporal lobes.

摘要

在死后的人类胎儿和成人脑中，测量了双侧半球颞上回（布罗德曼22区）和中央前回（布罗德曼4区）的胆碱乙酰转移酶（ChAT）活性。在胎儿脑中，右侧颞上回的ChAT值高于左侧（P<0.05）。相反，在成人大脑中，左侧颞上回的ChAT活性高于对侧（P<0.05）。胎儿和成人脑右侧颞上回的ChAT绝对值相似。在胎儿和成人的中央前回未发现不对称性。这些发现可以从左右颞叶胆碱能突触发育速率的差异来解释。