Queille C, Pommarede R, Saurat J H
Pediatr Dermatol. 1984 Jan;1(3):246-53. doi: 10.1111/j.1525-1470.1984.tb01124.x.
Six groups of children suffering from widespread atopic dermatitis were treated once daily with six topical steroids of different potency. Systemic effects were measured by the morning estimation of plasma cortisol. A clear relationship was demonstrated between clinical efficacy of the steroid treatment and degree of reduced adrenal function. This study demonstrated that a rapid and marked therapeutic effect can be obtained with potent topical steroids applied once daily without occlusion, but in children is accompanied by a fall in plasma cortisol.
六组患有广泛特应性皮炎的儿童每天接受一次不同效力的六种外用类固醇治疗。通过早晨测定血浆皮质醇来衡量全身效应。研究表明，类固醇治疗的临床疗效与肾上腺功能降低程度之间存在明确的关系。该研究表明，每日一次外用强效类固醇且不封包，可获得快速且显著的治疗效果，但在儿童中会伴随血浆皮质醇水平下降。
