Yamamoto H, Nagai K, Nakagawa H
Physiol Behav. 1984 Jun;32(6):1017-20. doi: 10.1016/0031-9384(84)90295-6.
The effects of intracranial injection of 2-deoxy-D-glucose (2DG) on the plasma free fatty acid (FFA) concentration and food intake in the light (11:00 hr) and dark (23:00 hr) period were examined in male Wistar rats under a 12-hr light (08:00-20:00) and 12-hr dark (20:00-08:00) cycle. In sham-operated rats 2DG injection induced increase in plasma FFA concentration and in food intake in the light period, but not in the dark period. Bilateral lesions of the suprachiasmatic nucleus (SCN) resulted in complete loss of the lipolytic and feeding responses to 2DG in the light period. From these findings it is concluded that the lipolytic and feeding responses to 2DG are photoperiodic and that the SCN is involved in these phenomena.
在12小时光照（08:00 - 20:00）和12小时黑暗（20:00 - 08:00）循环条件下，对雄性Wistar大鼠进行实验，研究颅内注射2 - 脱氧 - D - 葡萄糖（2DG）在光照期（11:00时）和黑暗期（23:00时）对血浆游离脂肪酸（FFA）浓度和食物摄入量的影响。在假手术大鼠中，2DG注射在光照期可引起血浆FFA浓度升高和食物摄入量增加，但在黑暗期则无此现象。视交叉上核（SCN）双侧损伤导致在光照期对2DG的脂解和进食反应完全丧失。从这些发现可以得出结论，对2DG的脂解和进食反应具有光周期特性，并且SCN参与了这些现象。
