Lundberg C, Gerdin B
Scand J Plast Reconstr Surg. 1984;18(2):175-80. doi: 10.3109/02844318409052834.
The role of histamine and serotonin in the inflammatory reaction in the granulation tissue of open wounds in the rat was studied. The model involved plastic chambers attached to the edges of two open circular full-thickness skin wounds. Five days post-wounding, agonists or antagonists were applied in one of the two chambers, the adjacent wound serving as control. Thereafter blood flow and albumin extravasation were measured. Application of histamine (100 microM) caused an increase in granulation tissue blood flow by 36%, but left albumin extravasation unaffected. Treatment with mepyramine (H1 antagonist, 20 microM), cimetidine (H2 antagonist, 20 microM) or methysergide (serotonin antagonist, 20 microM) did not influence the level of either blood flow or albumin extravasation. It is suggested that endogeneous histamine and serotonin play a minor role in the inflammatory process in the granulation tissue of this model of healing wounds.
研究了组胺和5-羟色胺在大鼠开放性伤口肉芽组织炎症反应中的作用。该模型包括附着于两个开放性圆形全层皮肤伤口边缘的塑料小室。伤后5天，在其中一个小室内应用激动剂或拮抗剂，相邻伤口作为对照。此后测量血流量和白蛋白外渗情况。应用组胺（100微摩尔）使肉芽组织血流量增加36%，但白蛋白外渗未受影响。用美吡拉敏（H1拮抗剂，20微摩尔）、西咪替丁（H2拮抗剂，20微摩尔）或甲基麦角新碱（5-羟色胺拮抗剂，20微摩尔）处理对血流量或白蛋白外渗水平均无影响。提示内源性组胺和5-羟色胺在该愈合伤口模型的肉芽组织炎症过程中起次要作用。
