人类T细胞分化抗原Leu-2/T8的基因与2号染色体上的κ轻链基因座紧密连锁。
Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2.
作者信息
Sukhatme V P, Vollmer A C, Erikson J, Isobe M, Croce C, Parnes J R
出版信息
J Exp Med. 1985 Feb 1;161(2):429-34. doi: 10.1084/jem.161.2.429.
Abstract
We have mapped the gene encoding the T cell differentiation antigen Leu-2/T8 to human chromosome 2 by hybridization of a Leu-2/T8 complementary DNA clone to DNA from a panel of mouse-human cell hybrids. In situ hybridization further localizes the gene to the 2p1 region in close proximity to the Ig kappa light chain gene. The Leu-2/T8 gene translocates with C kappa to chromosome 8 in a Burkitt lymphoma line carrying a t(2;8) translocation. These data support the hypothesis that Leu-2/T8 is the human homologue of the mouse Lyt-2,3 antigen.
摘要
我们通过将Leu-2/T8互补DNA克隆与一组小鼠-人类细胞杂交体的DNA进行杂交，已将编码T细胞分化抗原Leu-2/T8的基因定位到人类第2号染色体上。原位杂交进一步将该基因定位到2p1区域，紧邻免疫球蛋白κ轻链基因。在携带t(2;8)易位的伯基特淋巴瘤细胞系中，Leu-2/T8基因与Cκ一起易位到第8号染色体上。这些数据支持了Leu-2/T8是小鼠Lyt-2,3抗原的人类同源物这一假说。
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