人类1q23染色体上五聚体蛋白基因区域的精细定位
Fine mapping of the human pentraxin gene region on chromosome 1q23.
作者信息
Walsh M T, Divane A, Whitehead A S
机构信息
Department of Genetics and Biotechnology Institute, University of Dublin, Trinity College, Dublin, Ireland.
出版信息
Immunogenetics. 1996;44(1):62-9. doi: 10.1007/BF02602657.
The 1q21 to 25 region of human chromosome 1 contains genes which encode proteins with immune- and inflammation-associated functions. These include the pentraxin genes, for C-reactive protein (CRP), serum amyloid P (SAP) protein (APCS),a nd a CRP pseudogene (CRPP1). The region of chromosome 1 containing this cluster is syntenic with distal mouse chromosome 1. We constructed an approximately 1.4 megabase yeast artificial chromosome (YAC) contig with the pentraxin genes at its core. This four-YAC contig includes other genes with immune functions including the FCER1A gene, which encodes the alpha-subunit of the IgE high-affinity Fc receptor and the IFI-16 gene, an interferon-gamma-induced gene. In addition, it contains the histone H3F2 and H4F2 genes and the gene for erythroid alpha-spectrin (SPTA1). The gene order is cen.-SPTA1-H4F2-H3F2-IFI-16-CRP-CRPP1-APCS -FCER1A- tel. The contig thus consists of a cluster of genes whose products either have immunological importance, bind DNA, or both.
人类1号染色体的1q21至25区域包含一些基因，这些基因编码具有免疫和炎症相关功能的蛋白质。其中包括五聚体蛋白基因，如C反应蛋白（CRP）、血清淀粉样蛋白P（SAP）蛋白（APCS）以及一个CRP假基因（CRPP1）。包含该基因簇的1号染色体区域与小鼠1号染色体远端是同线的。我们构建了一个以五聚体蛋白基因为核心的约1.4兆碱基的酵母人工染色体（YAC）重叠群。这个由四个YAC组成的重叠群还包括其他具有免疫功能的基因，如编码IgE高亲和力Fc受体α亚基的FCER1A基因和干扰素γ诱导基因IFI-16基因。此外，它还包含组蛋白H3F2和H4F2基因以及红细胞α-血影蛋白（SPTA1）基因。基因顺序为着丝粒-SPTA1-H4F2-H3F2-IFI-16-CRP-CRPP1-APCS-FCER1A-端粒。因此，该重叠群由一组基因组成，这些基因的产物要么具有免疫学重要性，要么能结合DNA，或者两者兼具。
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