[Determination of the correlations between oxidant and antioxidant systems in bronchial asthma].

The authors devised a method for calculating the correlations of alpha-tocopherol and superoxide dismutase (SOD) activity to lipid peroxidation (LPO), presented in the form of the following coefficients: K1 = alpha-tocopherol/LPO, K2 = = SOD/LPO X 100. In patients with a bronchial asthma attack, there was an appreciable decrease in the K1 and K2 with a tendency toward recovery in the inactive disease phase. The coefficients ascended to relatively high values if the patients responded well to the treatment. As the disease duration increased (up to 5 years), there was a progressive lowering of the coefficients, with the LPO values being the highest and with those of alpha-tocopherol and SOD being low. The estimates under study were discovered to depend on the external respiration as shown by spirography and pneumotachometry. It has been demonstrated that the coefficients suggested by the authors characterize not only the level of the LPO-AOA system compensation but also of the pathological process on the whole. The data obtained point to the importance of determining the coefficients for the assessment of the patient's status gravity, the degree of the improvement following treatment, the disease gravity, and prognosis.