McLain D E, Roe D A
Teratology. 1984 Oct;30(2):203-10. doi: 10.1002/tera.1420300208.
Gastric intubation of 1.5 g ethanol/kg maternal body weight produced a significant teratogenic response in ferrets (Mustela putorius) treated once daily from gestational days 15 through 35. This response was evident by a rise in the frequency of fetuses with one or more malformations (21%), and by a rise in the frequency of litters with one or more malformed fetuses (50%). Palatoschisis and greater relative intermedial canthi distance observed in this study are diagnostic features of the fetal alcohol syndrome (FAS). Although mean (+/- SEM) peak blood alcohol levels of 207 +/- 9 mg/dl did not affect other reproductive parameters, high doses of alcohol (3.0 g/kg) resulted in the inability of treated females to consume adequate food or water, in the complete resorption of litters, and in significant maternal mortality (88%). Fetal deaths occurred prior to gestation day 17 in the high-dose alcohol group. Based on objective evaluation of differences among ethanol-treated, pair-fed sucrose-treated, and untreated ad libitum diet controls, the ferret would seem a valuable alternative animal species for future studies of FAS.
对孕期第15天至35天的雪貂（鼬属）每天进行一次胃插管，给予1.5克乙醇/千克母体体重，会产生显著的致畸反应。这种反应表现为出现一种或多种畸形的胎儿频率增加（21%），以及出现一个或多个畸形胎儿的窝数频率增加（50%）。本研究中观察到的腭裂和相对更大的内眦间距是胎儿酒精综合征（FAS）的诊断特征。尽管平均（±标准误）峰值血酒精水平为207±9毫克/分升并未影响其他生殖参数，但高剂量酒精（3.0克/千克）导致接受治疗的雌性动物无法摄入足够的食物或水，导致窝仔完全吸收，并导致显著的母体死亡率（88%）。高剂量酒精组在孕期第17天之前出现了胎儿死亡。基于对乙醇处理组、配对喂食蔗糖处理组和自由采食未处理对照组之间差异的客观评估，雪貂似乎是未来进行FAS研究的一种有价值的替代动物物种。
