Hallén B, Olsson G L, Uppfeldt A
Anaesthesia. 1984 Oct;39(10):969-72. doi: 10.1111/j.1365-2044.1984.tb08884.x.
This study was designed to assess the effect of time on the analgesic effect of a local anaesthetic cream consisting of a mixture of 5% lignocaine and prilocaine. The cream and placebo were compared in a double-blind, randomized study in 114 children aged 4-17 years, with application times of 20 minutes and longer. A regression analysis revealed no difference in analgesic effect between cream and placebo when application times were less than 60 minutes. A cusum test showed that the effect of the cream became evident at about 60 minutes. Local adverse reactions consisted mainly of transient paleness of the skin, which did not constitute any clinical problem.
本研究旨在评估时间对由5%利多卡因和丙胺卡因混合而成的局部麻醉乳膏镇痛效果的影响。在一项双盲、随机研究中，对114名4至17岁儿童使用该乳膏和安慰剂进行比较，涂抹时间为20分钟及更长时间。回归分析显示，当涂抹时间少于60分钟时，乳膏和安慰剂的镇痛效果无差异。累积和检验表明，乳膏的效果在约60分钟时变得明显。局部不良反应主要为皮肤短暂苍白，不构成任何临床问题。
