Maunuksela E L, Korpela R
Br J Anaesth. 1986 Nov;58(11):1242-5. doi: 10.1093/bja/58.11.1242.
The effect of the topical application of a lignocaine-prilocaine cream (EMLA) on the pain of venous cannulation was tested in a double-blind manner. Sixty boys and girls between the ages of 4 and 10 yr who were to undergo surgery participated in the study. No analgesic premedication was given and the venous cannulation was performed during the preparation for general anaesthesia. Pain was assessed by the anaesthetist and the patient using a verbal rating scale and two different pictorial scales. The effect of EMLA in the alleviation of the pain of venous cannulation was considered significantly better than placebo by both anaesthetist (P less than 0.001) and patient (P less than 0.05) (verbal scales). One conventional pictorial scale showed a statistically significant difference (P less than 0.05), but the other, based on facial expressions, did not. Local reactions to the cream were minor and transient in both groups.
采用双盲法测试了利多卡因-丙胺卡因乳膏（EMLA）局部应用对静脉穿刺疼痛的影响。60名年龄在4至10岁之间即将接受手术的男孩和女孩参与了该研究。未给予镇痛前用药，静脉穿刺在全身麻醉准备期间进行。麻醉师和患者使用言语评定量表和两种不同的图像量表评估疼痛。麻醉师（P＜0.001）和患者（P＜0.05）（言语量表）均认为EMLA在减轻静脉穿刺疼痛方面的效果明显优于安慰剂。一种传统的图像量表显示出统计学上的显著差异（P＜0.05），但另一种基于面部表情的量表则未显示出差异。两组对乳膏的局部反应均轻微且短暂。
