Linn W S, Avol E L, Shamoo D A, Venet T G, Anderson K R, Whynot J D, Hackney J D
Arch Environ Health. 1984 Jul-Aug;39(4):313-9. doi: 10.1080/00039896.1984.10545856.
Asthmatic volunteers (N = 14) aged 18 to 33 yr with documented sensitivity to sulfur dioxide (SO2) were exposed in a chamber to 0.6 ppm SO2 for 6-hr periods on 2 successive days. Similar exposures to purified air, 1 wk later or earlier, served as controls. Subjects exercised heavily (target ventilation rate 50 L/min) for 5 min near the beginning of exposure (early exercise) and for an additional 5 min beginning after 5-hr of exposure (late exercise). At all other times, they rested. Body plethysmographic measurements and symptom questionnaires were administered pre-exposure, after each exercise period, and hourly during rest. Bronchoconstriction and lower respiratory symptoms were observed during or immediately following exercise--to a slight extent with clean air, and to a more marked extent with SO2. Bronchoconstriction and symptoms were modestly less severe on the second day of SO2 exposure than on the first day, but there were no meaningful differences in response between early and late exercise periods on either day.
14名年龄在18至33岁之间、有二氧化硫（SO₂）敏感记录的哮喘志愿者在一个舱室内连续两天每天暴露于0.6 ppm的SO₂中6小时。一周后或更早时候，让他们暴露于净化空气中作为对照。在暴露开始时（早期运动），受试者进行5分钟的剧烈运动（目标通气率50升/分钟），在暴露5小时后再进行5分钟的运动（晚期运动）。在其他所有时间，他们休息。在暴露前、每个运动阶段后以及休息期间每小时进行体容积描记测量和症状问卷调查。在运动期间或运动后立即观察到支气管收缩和下呼吸道症状——在清洁空气中症状较轻，在SO₂中症状更明显。与第一天相比，在SO₂暴露的第二天，支气管收缩和症状的严重程度略有减轻，但在任何一天的早期和晚期运动阶段之间，反应没有显著差异。
