Hackney J D, Linn W S, Bailey R M, Spier C E, Valencia L M
Environ Res. 1984 Aug;34(2):321-7. doi: 10.1016/0013-9351(84)90100-2.
Young adult asthmatic volunteers (N = 17) were exposed to 0.75 ppm sulfur dioxide (SO2) for 3-hr periods, exercising vigorously for the first 10 min and resting thereafter. Specific airway resistance (SRaw) and symptoms were recorded preexposure, immediately postexercise, and after 1, 2, and 3 hr of exposure. Symptoms and SRaw were significantly increased after exercise, relative to preexposure measurements. Group mean SRaw and symptom increases were no longer significant at 1 hr. In a few individuals, effects may have persisted for 2 hr or more. On separate occasions, comparable exposures were conducted, and forced expiratory spirometry was performed preexposure and postexercise, in addition to the other tests. Inclusion of spirometry did not significantly affect the other results. Spirometry and SRaw showed nearly equal significance in changes postexercise. Thus, in general, asthmatics' bronchoconstriction induced by exercise in SO2 seems to reverse quickly with rest, even if SO2 exposure continues. Spirometry may be useful for studying pollution-induced bronchoconstriction when SRaw measurements are impractical.
年轻成年哮喘志愿者（N = 17）暴露于0.75 ppm的二氧化硫（SO2）中3小时，前10分钟剧烈运动，之后休息。在暴露前、运动后即刻以及暴露1、2和3小时后记录比气道阻力（SRaw）和症状。与暴露前测量相比，运动后症状和SRaw显著增加。1小时时，组平均SRaw和症状增加不再显著。在少数个体中，影响可能持续2小时或更长时间。在不同时间进行了类似暴露，并在暴露前和运动后进行了用力呼气肺活量测定，以及其他测试。纳入肺活量测定并未显著影响其他结果。肺活量测定和SRaw在运动后变化中显示出几乎相同的显著性。因此，一般来说，即使继续暴露于SO2，哮喘患者在SO2中运动诱发的支气管收缩似乎在休息后会迅速逆转。当SRaw测量不切实际时，肺活量测定可能有助于研究污染诱发的支气管收缩。
