钴取代的血红蛋白和肌红蛋白通过偶联氧化形成胆色素。
Formation of bile pigments by coupled oxidation of cobalt-substituted haemoglobin and myoglobin.
作者信息
Vernon D I, Brown S B
出版信息
Biochem J. 1984 Oct 1;223(1):205-9. doi: 10.1042/bj2230205.
Abstract
Treatment of cobalt-substituted haemoglobin and myoglobin with ascorbate and molecular O2 (coupled oxidation) resulted in biliverdin formation from the cobalt(II) derivatives but not from the cobalt(III) derivatives. This was apparently due to the inability of ascorbate to reduce cobalt(III) haemoproteins. Isomer analysis of the biliverdins produced from coupled oxidation of cobalt(II) oxyhaemoglobin suggested that the orientation of the cobalt protoporphyrin IX in the haem pocket differed slightly from that of the haem in native haemoglobin.
摘要
用抗坏血酸盐和分子氧（偶联氧化）处理钴取代的血红蛋白和肌红蛋白，钴（II）衍生物可形成胆绿素，而钴（III）衍生物则不能。这显然是由于抗坏血酸盐无法还原钴（III）血红素蛋白。对钴（II）氧合血红蛋白偶联氧化产生的胆绿素进行的异构体分析表明，血红素口袋中钴原卟啉IX的取向与天然血红蛋白中血红素的取向略有不同。
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