钴取代的血红蛋白和肌红蛋白通过偶联氧化形成胆色素。
Formation of bile pigments by coupled oxidation of cobalt-substituted haemoglobin and myoglobin.
作者信息
Vernon D I, Brown S B
出版信息
Biochem J. 1984 Oct 1;223(1):205-9. doi: 10.1042/bj2230205.
Abstract
Treatment of cobalt-substituted haemoglobin and myoglobin with ascorbate and molecular O2 (coupled oxidation) resulted in biliverdin formation from the cobalt(II) derivatives but not from the cobalt(III) derivatives. This was apparently due to the inability of ascorbate to reduce cobalt(III) haemoproteins. Isomer analysis of the biliverdins produced from coupled oxidation of cobalt(II) oxyhaemoglobin suggested that the orientation of the cobalt protoporphyrin IX in the haem pocket differed slightly from that of the haem in native haemoglobin.
摘要
用抗坏血酸盐和分子氧（偶联氧化）处理钴取代的血红蛋白和肌红蛋白，钴（II）衍生物可形成胆绿素，而钴（III）衍生物则不能。这显然是由于抗坏血酸盐无法还原钴（III）血红素蛋白。对钴（II）氧合血红蛋白偶联氧化产生的胆绿素进行的异构体分析表明，血红素口袋中钴原卟啉IX的取向与天然血红蛋白中血红素的取向略有不同。
相似文献
1
Formation of bile pigments by coupled oxidation of cobalt-substituted haemoglobin and myoglobin.钴取代的血红蛋白和肌红蛋白通过偶联氧化形成胆色素。
Biochem J. 1984 Oct 1;223(1):205-9. doi: 10.1042/bj2230205.
2
Urinary excretion of isomers of biliverdin after destruction in vivo of haemoproteins and haemin.血蛋白和血红素在体内被破坏后胆绿素异构体的尿排泄情况。
Biochem J. 1985 Jul 15;229(2):477-83. doi: 10.1042/bj2290477.
3
Verdohemochrome IX alpha: preparation and oxidoreductive cleavage to biliverdin IX alpha.胆绿血红蛋白IXα：制备及氧化还原裂解为胆绿素IXα
Proc Natl Acad Sci U S A. 1982 Mar;79(5):1393-7. doi: 10.1073/pnas.79.5.1393.
4
Sequence of heme decomposition by the coupled oxidation of myoglobin with ascorbic acid.
Tohoku J Exp Med. 1975 Jan;115(1):67-74. doi: 10.1620/tjem.115.67.
5
Methine-bridge specificity of the coupled oxidation of myoglobin and haemoglobin with ascorbate.肌红蛋白和血红蛋白与抗坏血酸的偶联氧化反应中亚甲基桥的特异性
Biochem J. 1970 Oct;119(5):42P-43P. doi: 10.1042/bj1190042p.
6
Haem degradation in human haemoglobin in vitro. Separation of the contribution of the alpha- and beta-subunits.人血红蛋白在体外的血红素降解。α亚基和β亚基贡献的分离。
Biochem J. 1984 Sep 1;222(2):401-6. doi: 10.1042/bj2220401.
7
The mechanism of haem catabolism. A study of haem breakdown in spleen microsomal fraction and in a model system by 18O labelling and metal substitution.血红素分解代谢的机制。通过18O标记和金属替代对脾脏微粒体部分和模型系统中血红素分解的研究。
Biochem J. 1978 Jul 15;174(1):103-9. doi: 10.1042/bj1740103.
8
Coupled oxidation of myoglobin with ascorbate as a model of haem brakdown in vivo.以肌红蛋白与抗坏血酸盐的偶联氧化作为体内血红素分解的模型。
Biochem J. 1969 Nov;115(3):13P-14P. doi: 10.1042/bj1150013pb.
9
Metabolism of biliverdin. Biliary excretion of bile pigments after intravenous injection of biliverdin isomers.胆绿素的代谢。静脉注射胆绿素异构体后胆汁色素的胆汁排泄。
Biochim Biophys Acta. 1976 Sep 24;444(2):333-7. doi: 10.1016/0304-4165(76)90375-5.
10
Orientation of oxygen in oxyhaemoproteins and its implications for haem catabolism.氧合血红蛋白中氧的取向及其对血红素分解代谢的影响。
Nature. 1981 Jan 1;289(5793):93-5. doi: 10.1038/289093a0.
引用本文的文献
1
Disruption of monocyte-macrophage differentiation and trafficking by a heme analog during active inflammation.活性炎症期间，血红素类似物对单核细胞-巨噬细胞分化和迁移的破坏作用。
Mucosal Immunol. 2022 Feb;15(2):244-256. doi: 10.1038/s41385-021-00474-8. Epub 2021 Dec 16.
2
Heme Inhibition of [delta]-Aminolevulinic Acid Synthesis Is Enhanced by Glutathione in Cell-Free Extracts of Chlorella.在小球藻的无细胞提取物中，谷胱甘肽可增强血红素对δ-氨基乙酰丙酸合成的抑制作用。
Plant Physiol. 1993 Feb;101(2):657-665. doi: 10.1104/pp.101.2.657.
本文引用的文献
1
Studies on the heterogeneity of hemoglobin. V. Binding of hemoglobin with oxidized glutathione.血红蛋白异质性研究。V. 血红蛋白与氧化型谷胱甘肽的结合
J Lab Clin Med. 1962 Aug;60:302-19.
2
PREPARATIONS, PROPERTIES, AND SPECIFIC RECOMBINATION OF ALPHA-BETA-GLOBIN SUBUNITS.α-β-珠蛋白亚基的制备、性质及特异性重组
J Biol Chem. 1964 Nov;239:3699-705.
3
HAEM catabolism and coupled oxidation of haemproteins.血红素分解代谢与血红素蛋白的偶联氧化
FEBS Lett. 1969 Nov 29;5(4):295-298. doi: 10.1016/0014-5793(69)80372-8.
4
Orientation of oxygen in oxyhaemoproteins and its implications for haem catabolism.氧合血红蛋白中氧的取向及其对血红素分解代谢的影响。
Nature. 1981 Jan 1;289(5793):93-5. doi: 10.1038/289093a0.
5
Proton nuclear nagnetic resonance characterization of heme disorder in monomeric insect hemoglobins.单体昆虫血红蛋白中血红素紊乱的质子核磁共振表征
J Biol Chem. 1980 Jan 10;255(1):66-70.
6
Haem disorder in reconstituted human haemoglobin.重组人血红蛋白中的血液疾病。
Biochem J. 1982 Dec 1;207(3):583-7. doi: 10.1042/bj2070583.
7
Studies on cobalt myoglobins and hemoglobins. I. Preparation and optical properties of myoglobins and hemoglobins containing cobalt proto-, meso-, and deuteroporphyrins and thermodynamic characterization of their reversible oxygenation.钴肌红蛋白和血红蛋白的研究。I. 含原卟啉钴、中卟啉钴和次卟啉钴的肌红蛋白和血红蛋白的制备及其光学性质，以及它们可逆氧合的热力学表征。
J Biol Chem. 1974 Feb 10;249(3):682-90.
8
Activity of various metalloporphyrin protein complexes with microsomal heme oxygenase.各种金属卟啉蛋白复合物与微粒体血红素加氧酶的活性。
Life Sci. 1974 Jan 1;14(1):47-53. doi: 10.1016/0024-3205(74)90244-6.
9
The meso-reactivity of porphyrins and related compounds. VI. Oxidative cleavage of the haem system. The four isomeric biliverdins of the IX series.卟啉及相关化合物的中位反应活性。VI. 血红素系统的氧化裂解。IX系列的四种异构胆绿素。
J Chem Soc Perkin 1. 1973;9:881-8. doi: 10.1039/p19730000881.
10
The meso-reactivity of porphyrins and related compounds. V. The meso-oxidation of metalloporphyrins.卟啉及相关化合物的中位反应活性。V. 金属卟啉的中位氧化
J Chem Soc Perkin 1. 1972;20:2540-8. doi: 10.1039/p19720002540.
Zotero 插件