Barker D J, Godfrey K M
Br J Cancer. 1984 Nov;50(5):693-8. doi: 10.1038/bjc.1984.238.
The incidence of colorectal cancer was compared in nine towns in England and Wales, chosen to encompass a range of socio-economic conditions and spread of latitude in the country. Cases were ascertained through pathology records, supplemented by clinical notes. The pattern of variation in incidence was different for men and women. Among men incidences were highest in towns with better socio-economic conditions, whereas among women the trend was reversed. This supports the hypothesis that the dominant aetiological influences causing colorectal cancer differ in the two sexes. Mortality rates did not correlate closely with incidence. This, together with the markedly different patterns of incidence of colorectal cancer and appendicitis in the nine towns, casts doubt on the significance of a reported inverse correlation between regional mortality from colonic cancer and the consumption of pentosic fibre.
对英格兰和威尔士的9个城镇的结直肠癌发病率进行了比较，这些城镇的选择涵盖了该国一系列社会经济状况和纬度分布。通过病理记录确定病例，并辅以临床记录。男性和女性的发病率变化模式不同。在男性中，社会经济状况较好的城镇发病率最高，而在女性中，趋势则相反。这支持了这样一种假设，即导致结直肠癌的主要病因影响在两性中有所不同。死亡率与发病率没有密切关联。这一点，再加上这9个城镇中结直肠癌和阑尾炎发病率的明显不同模式，让人对所报道的结肠癌区域死亡率与戊糖纤维消费量之间的负相关关系的重要性产生怀疑。
