流感病毒感染的人淋巴母细胞中的病毒神经氨酸酶和细胞外唾液酸转移酶

Viral neuraminidase and cellular ectosialyltransferase in human lymphoblastoid cells infected with influenza virus.

作者信息

Duc Dodon M, Cecchelli R, Cacan R, Gazzolo L, Verbert A

出版信息

Biochimie. 1984 Jun;66(6):493-6. doi: 10.1016/0300-9084(84)90086-5.

Abstract

In human lymphoblastoid cells, infected with an influenza virus, Fowl Plague Virus (FPV), glycoproteins (such as secreted IgM) are hyposialylated, through the action of viral neuraminidase. In this study, the modulation of the cellular ectosialyltransferase activity during viral infection was investigated. This activity was detectable in FPV-infected cells, was shown to be 2.5-fold higher than that of uninfected cells, and to be able to restore, at least partially, the level of sialylation of the cell surface acceptors.

摘要

在感染流感病毒——禽瘟病毒（FPV）的人淋巴母细胞中，糖蛋白（如分泌型IgM）通过病毒神经氨酸酶的作用而低唾液酸化。在本研究中，对病毒感染期间细胞外唾液酸转移酶活性的调节进行了研究。这种活性在感染FPV的细胞中可检测到，结果表明其比未感染细胞的活性高2.5倍，并且能够至少部分恢复细胞表面受体的唾液酸化水平。