Pekelharing J M, Hepp E, Kamerling J P, Gerwig G J, Leijnse B
Department of Clinical Chemistry, Stichting Samenwerking Delfts Ziekenhuizen, The Netherlands.
Ann Rheum Dis. 1988 Feb;47(2):91-5. doi: 10.1136/ard.47.2.91.
The carbohydrate composition of IgG purified from serum of patients with rheumatoid arthritis (RA), pregnant women, and blood donors has been determined by gas-liquid chromatography. Comparison of the results indicates that IgG from patients with RA contains significantly less galactose but more N-acetylglucosamine than normal IgG, whereas the fucose and sialic acid contents are not changed. The carbohydrate content of IgG in RA is reduced. IgG in pregnancy contains more galactose and more sialic acid than normal IgG, whereas fucose, N-acetylglucosamine, and the total carbohydrate content are not changed. These data suggest a temporal compensation of the RA associated undergalactosylation of IgG in female patients with RA during pregnancy, a period during which remission of the disease is often observed.
通过气液色谱法测定了从类风湿性关节炎（RA）患者、孕妇和献血者血清中纯化的IgG的碳水化合物组成。结果比较表明，RA患者的IgG所含半乳糖明显少于正常IgG，但N - 乙酰葡糖胺更多，而岩藻糖和唾液酸含量没有变化。RA患者IgG的碳水化合物含量降低。孕期IgG所含半乳糖和唾液酸比正常IgG更多，而岩藻糖、N - 乙酰葡糖胺和总碳水化合物含量没有变化。这些数据表明，在孕期，女性RA患者中与RA相关的IgG半乳糖基化不足会出现暂时补偿，在此期间疾病常常缓解。
