类风湿关节炎患者及孕妇血清IgG碳水化合物组成的改变。
Alterations in carbohydrate composition of serum IgG from patients with rheumatoid arthritis and from pregnant women.
作者信息
Pekelharing J M, Hepp E, Kamerling J P, Gerwig G J, Leijnse B
机构信息
Department of Clinical Chemistry, Stichting Samenwerking Delfts Ziekenhuizen, The Netherlands.
出版信息
Ann Rheum Dis. 1988 Feb;47(2):91-5. doi: 10.1136/ard.47.2.91.
Abstract
The carbohydrate composition of IgG purified from serum of patients with rheumatoid arthritis (RA), pregnant women, and blood donors has been determined by gas-liquid chromatography. Comparison of the results indicates that IgG from patients with RA contains significantly less galactose but more N-acetylglucosamine than normal IgG, whereas the fucose and sialic acid contents are not changed. The carbohydrate content of IgG in RA is reduced. IgG in pregnancy contains more galactose and more sialic acid than normal IgG, whereas fucose, N-acetylglucosamine, and the total carbohydrate content are not changed. These data suggest a temporal compensation of the RA associated undergalactosylation of IgG in female patients with RA during pregnancy, a period during which remission of the disease is often observed.
摘要
通过气液色谱法测定了从类风湿性关节炎（RA）患者、孕妇和献血者血清中纯化的IgG的碳水化合物组成。结果比较表明，RA患者的IgG所含半乳糖明显少于正常IgG，但N - 乙酰葡糖胺更多，而岩藻糖和唾液酸含量没有变化。RA患者IgG的碳水化合物含量降低。孕期IgG所含半乳糖和唾液酸比正常IgG更多，而岩藻糖、N - 乙酰葡糖胺和总碳水化合物含量没有变化。这些数据表明，在孕期，女性RA患者中与RA相关的IgG半乳糖基化不足会出现暂时补偿，在此期间疾病常常缓解。
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本文引用的文献
1
Variations in the relative proportions of microheterogeneous forms of plasma glycoproteins in pregnancy and disease.妊娠和疾病中血浆糖蛋白微不均一形式相对比例的变化。
Biomed Pharmacother. 1982 Mar;36(2):77-86.
2
The successful use of asialylated IgG as an immunogen and arthritogen in the rabbit.去唾液酸IgG在兔中作为免疫原和致关节炎原的成功应用。
Immunology. 1983 Jul;49(3):511-8.
3
Effect of pregnancy on immune complexes and rheumatoid factors in patients with rheumatoid arthritis.妊娠对类风湿关节炎患者免疫复合物及类风湿因子的影响。
Am J Med. 1983 Jun;74(6):973-9. doi: 10.1016/0002-9343(83)90794-5.
4
Effect of pregnancy and hormonal changes on the activity of rheumatoid arthritis.妊娠及激素变化对类风湿关节炎活动的影响。
Scand J Rheumatol. 1983;12(2):69-72. doi: 10.3109/03009748309102886.
5
Structural and numerical variations of the carbohydrate moiety of immunoglobulin G.免疫球蛋白G碳水化合物部分的结构和数值变异
J Immunol. 1982 Nov;129(5):2016-20.
6
Viral neuraminidase and cellular ectosialyltransferase in human lymphoblastoid cells infected with influenza virus.流感病毒感染的人淋巴母细胞中的病毒神经氨酸酶和细胞外唾液酸转移酶
Biochimie. 1984 Jun;66(6):493-6. doi: 10.1016/0300-9084(84)90086-5.
7
The antigenicity of asialylated IgG: its relationship to rheumatoid factor.去唾液酸IgG的抗原性：其与类风湿因子的关系。
Immunology. 1981 Mar;42(3):401-8.
8
Oral contraceptives and rheumatoid arthritis: further evidence for a preventive effect.口服避孕药与类风湿关节炎：预防作用的进一步证据。
Lancet. 1982 Oct 16;2(8303):839-42. doi: 10.1016/s0140-6736(82)90809-1.
9
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Semin Arthritis Rheum. 1984 Aug;14(1):1-23. doi: 10.1016/0049-0172(84)90005-2.
10
Noncontraceptive hormones and rheumatoid arthritis in perimenopausal and postmenopausal women.围绝经期和绝经后女性的非避孕激素与类风湿关节炎
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