Cunliffe W J, Hasleton P S, Tweedle D E, Schofield P F
Br J Surg. 1984 Dec;71(12):941-3. doi: 10.1002/bjs.1800711210.
Two hundred and twenty-three patients with colorectal carcinoma were treated consecutively at the University Hospital of South Manchester from May 1976 to January 1981. Twenty-four patients (10.7 per cent) were found to have more than one colorectal carcinoma. In 18 patients this was recognized either immediately or within 6 months of the initial diagnosis--synchronous carcinoma. In the other six cases a second carcinoma was found at a later time--metachronous carcinoma. The incidence of synchronous, and consequently the combined incidence of synchronous and metachronous carcinoma, was higher than previously documented. The anatomical distribution of the multiple carcinomas and the sex incidence in these patients was similar to that seen in patients with a single carcinoma of the large bowel. A high association of adenomatous polypi with multiple large bowel carcinomas was observed. The possibility of more extensive colonic resection in the younger patient with a favourable carcinoma is discussed.
1976年5月至1981年1月期间，南曼彻斯特大学医院对223例结直肠癌患者进行了连续治疗。发现24例患者（10.7%）患有不止一处结直肠癌。其中18例患者在初次诊断时或诊断后的6个月内就被确诊为同时性癌。另外6例患者在之后的时间里被发现患有第二处癌症，即异时性癌。同时性癌的发生率，以及因此同时性癌和异时性癌的合并发生率，均高于先前记录的水平。这些患者中多发癌的解剖分布和性别发生率与大肠单发癌患者相似。观察到腺瘤性息肉与多发大肠癌之间存在高度关联。文中讨论了年轻患者中患预后良好的癌症时进行更广泛结肠切除术的可能性。
