Törnqvist A, Ekelund G, Leandoer L
Aust N Z J Surg. 1981 Oct;51(5):442-5. doi: 10.1111/j.1445-2197.1981.tb05980.x.
The frequency of metachronous colorectal tumours in a prospective 20-year series of patients with colorectal cancer is reported. Thirty-one patients, that is 2.1% of the patients operated on for cure, had metachronous carcinomas, and 5.4% had metachronous polyps. One-third of the metachronous carcinomas were diagnosed at scheduled postoperative control examinations, and the others because of their symptoms or at autopsy. The reported metachronous carcinomas are considered to represent failures of follow-up only and not to indicate their true incidence, since their natural course has been arrested by removal of adenomas whenever found. Several of the metachronous tumours were judged to be overlooked synchronous ones, and therefore a thorough postoperative examination of the remaining large bowel is advocated. The finding of subsequent tumours in this series indicates that continuous follow-up is worthwhile.
报告了一组前瞻性20年结直肠癌患者中异时性结直肠肿瘤的发生频率。31例患者（即接受根治性手术患者的2.1%）发生了异时性癌，5.4%的患者有异时性息肉。三分之一的异时性癌在术后定期复查时被诊断出来，其他的则是由于出现症状或在尸检时发现。所报告的异时性癌仅被认为是随访失败的结果，而不能表明其真实发病率，因为一旦发现腺瘤就将其切除，其自然病程已被阻断。一些异时性肿瘤被判定为被漏诊的同时性肿瘤，因此主张对剩余大肠进行全面的术后检查。在这组病例中发现后续肿瘤表明持续随访是值得的。
