Vobecky J, Devroede G, Caro J
Cancer. 1984 Dec 1;54(11):2537-42. doi: 10.1002/1097-0142(19841201)54:11<2537::aid-cncr2820541138>3.0.co;2-q.
In a previous study, the authors found an increased incidence of colorectal cancer among workers in a textile factory producing synthetic fiber. To answer the crucial question of whether the risk is confined to one section of the plant, a case-control study was done. For each of 43 cancers that occurred in the plant between 1965 and 1979, 3 controls were selected at random from company files of 24,270 current and past employees. They were matched for age, date of beginning employment, and duration of employment. Forty-four percent of the cancer patients worked in one of three departments: "extrusion D," "extrusion TM," and "textile," whereas only 21% of the controls worked in one of these departments (P less than 0.005). After 1974, when the peak incidence was observed, 10 of 21 patients had worked in either or both extrusion departments; only 8 of 63 controls had worked in these departments. (P less than 0.002). It took more than 10 years (10 of 33 cases versus 8 of 95 controls; P less than 0.002) before a risk became apparent. According to work areas, the relative risk was increased for those who had worked in building 3, where the extrusion D department was located (P less than 0.02). These results offer a basis for the prevention and surveillance of colorectal cancer in this industry.
在之前的一项研究中，作者发现一家生产合成纤维的纺织厂的工人中，结直肠癌的发病率有所上升。为了回答风险是否仅限于工厂的某一部门这一关键问题，开展了一项病例对照研究。对于1965年至1979年间该厂发生的43例癌症病例，从24270名现任和前任员工的公司档案中随机选取3名对照。根据年龄、开始工作日期和工作时长进行匹配。44%的癌症患者在三个部门之一工作：“挤出D部”、“挤出TM部”和“纺织部”，而只有21%的对照在这些部门之一工作（P小于0.005）。1974年后，观察到发病率达到峰值，21例患者中有10例曾在一个或两个挤出部门工作；63名对照中只有8人曾在这些部门工作（P小于0.002）。风险显现之前需要超过10年的时间（33例病例中有10例，95名对照中有8例；P小于0.002）。根据工作区域，在3号楼工作的人（挤出D部所在楼）相对风险增加（P小于0.02）。这些结果为该行业结直肠癌的预防和监测提供了依据。
