Ron M, Menashe M, Hochner-Celnikier D, Palti Z
Eur J Obstet Gynecol Reprod Biol. 1984 Sep;18(1-2):25-8. doi: 10.1016/0028-2243(84)90029-7.
A double blind study on the effect of an intravenous injection of a combination of 75 mg pethidine and 25 mg promethazine was conducted on 200 women during normal deliveries. Four groups of 50 women each received injections of pethidine and promethazine, promethazine alone, pethidine alone and normal saline. In the pethidine-promethazine group there was a significant elevation in blood pressure in the first 10 min following the injection as compared with the other groups. The mean (+/- S.D.) systolic blood pressure after the injection was 143.2 +/- 14.3 mmHg as compared with 118.9 +/- 8.4 mmHg before the injection, and the mean diastolic blood pressure as 96.9 +/- 8.4 mmHg after the injection as compared with 77.7 +/- 9.3 mmHg before the injection. 25 mg promethazine alone caused slight elevation in blood pressure which was further increased by combination with pethidine. The clinical significance of these observations is discussed.
对200名正常分娩的女性进行了一项双盲研究，以观察静脉注射75毫克哌替啶与25毫克异丙嗪组合的效果。四组，每组50名女性，分别接受了哌替啶和异丙嗪联合注射、单独注射异丙嗪、单独注射哌替啶以及注射生理盐水。与其他组相比，哌替啶 - 异丙嗪组在注射后的前10分钟血压显著升高。注射后平均（±标准差）收缩压为143.2±14.3毫米汞柱，而注射前为118.9±8.4毫米汞柱；注射后平均舒张压为96.9±8.4毫米汞柱，而注射前为77.7±9.3毫米汞柱。单独使用25毫克异丙嗪会使血压略有升高，与哌替啶联合使用后血压进一步升高。讨论了这些观察结果的临床意义。
