Biggar W D, Bohn D J, Kent G, Barker C, Hamilton G
Infect Immun. 1984 Dec;46(3):857-9. doi: 10.1128/iai.46.3.857-859.1984.
The effect of hypothermia on pig leukocyte migration in vitro and in vivo was studied. Neutrophil chemotaxis in vitro under agarose was significantly impaired at 29 degrees C (2.7 +/- 0.6 [mean +/- standard error]; 37 degrees C, 7.1 +/- 1.1). Leukocytes isolated from hypothermic pigs and tested at 37 degrees C migrated normally (7.8 +/- 0.6). Neutrophil and monocyte migration in vivo was markedly reduced at 29 degrees C. Reduced inflammatory responses may contribute to increased infections during hypothermia.
研究了低温对猪体外和体内白细胞迁移的影响。在29摄氏度时,琼脂糖下的体外中性粒细胞趋化性显著受损(2.7±0.6[平均值±标准误差];37摄氏度时为7.1±1.1)。从低温猪分离出的白细胞在37摄氏度下测试时迁移正常(7.8±0.6)。在29摄氏度时,体内中性粒细胞和单核细胞的迁移明显减少。炎症反应减弱可能导致低温期间感染增加。