Issekutz T B, Issekutz A C, Movat H Z
Am J Pathol. 1981 Apr;103(1):47-55.
Mononuclear leukocytes isolated from the blood of rabbits, were labeled with 51Cr and returned to the animal intravenously. 51Cr-labeled monocytes disappeared from the blood with a half-life of 39.0 +/- 2.51 hours. Numerous acute inflammatory lesions were produced by the intradermal injection of Escherichia coli into the skin of the back of a rabbit. The animal was sacrificed after 1 hour, and the radioactivity in each lesion was determined. Monocyte accumulation was substantial by the time a lesion was 1 hour old. The maximum rate of accumulation occurred at 3--4 hours, and monocytes continued to enter the lesions at 25% of the maximal rate for at least 24 hours. Monocytes initially migrate into bacterial inflammatory sites simultaneously with neutrophils and histologically become the predominant cell type after 12 hours because they continue to migrate into these lesions long after neutrophils have stopped. The kinetics of monocyte migration is related to other aspects of inflammation.
从兔血液中分离出的单核白细胞，用51Cr进行标记后静脉回输给动物。51Cr标记的单核细胞从血液中消失的半衰期为39.0±2.51小时。通过在兔背部皮肤皮内注射大肠杆菌产生大量急性炎症病变。1小时后处死动物，测定每个病变中的放射性。当病变形成1小时时，单核细胞大量聚集。最大聚集速率出现在3 - 4小时，单核细胞以最大速率的25%持续进入病变至少24小时。单核细胞最初与中性粒细胞同时迁移到细菌性炎症部位，并且在组织学上12小时后成为主要细胞类型，因为在中性粒细胞停止迁移很久之后它们仍继续迁移到这些病变中。单核细胞迁移的动力学与炎症的其他方面有关。
