Olsen J H, Jensen S P, Hink M, Faurbo K, Breum N O, Jensen O M
Int J Cancer. 1984 Nov 15;34(5):639-44. doi: 10.1002/ijc.2910340509.
A comprehensive data linkage system for the detailed investigation of occupational cancer has newly been established in the Danish Cancer Registry, providing employment histories back until 1964. Based on this system a study of 839 cases of cancer of the nasal cavities, sinuses and rhinopharnyx and 2,465 cancer controls diagnosed in Denmark during the period 1970-1982 was conducted. Histories of exposure to formaldehyde, wood-dust and 10 other specified compounds or procedures, were assessed by industrial hygienists unaware of the case-control status of the cancer patients under study. Some 4.2% of the male and 0.1% of the female controls had been exposed to formaldehyde. A statistically significant excess risk (p less than 0.05) for carcinoma of the nasal cavity and sinuses among males with a history of exposure to formaldehyde (RR = 2.8), wood-dust (RR = 2.5) and paint lacquer and glue (RR = 2.1) was found. When adjustment was made for wood-dust exposure the relative risk associated with formaldehyde was reduced to 1.6, which is not significantly in excess of 1.0, although still compatible with a 3- to 4-fold increase in risk using conventional 95% confidence limits. The joint action of exposure to wood-dust and formaldehyde was in accordance with an additive effect. The excess risk of sino-nasal cancer with exposure to paint, lacquer and glue remained statistically elevated after adjustment for contemporary exposure to wood-dust and formaldehyde.
丹麦癌症登记处新建立了一个综合数据链接系统，用于详细调查职业性癌症，可提供追溯至1964年的就业史。基于该系统，对1970年至1982年期间在丹麦诊断出的839例鼻腔、鼻窦和鼻咽癌症病例以及2465例癌症对照进行了研究。甲醛、木尘和其他10种特定化合物或工序的接触史，由不了解所研究癌症患者病例对照状态的工业卫生学家进行评估。约4.2%的男性对照和0.1%的女性对照曾接触过甲醛。在有甲醛接触史（RR = 2.8）、木尘接触史（RR = 2.5）以及油漆、清漆和胶水接触史（RR = 2.1）的男性中，鼻腔和鼻窦癌存在统计学上显著的超额风险（p小于0.05）。在对木尘接触进行调整后，与甲醛相关的相对风险降至1.6，虽然使用传统95%置信区间时仍与风险增加3至4倍相符，但未显著超过1.0。木尘和甲醛接触的联合作用符合相加效应。在对同时期木尘和甲醛接触进行调整后，接触油漆、清漆和胶水导致的鼻窦癌超额风险在统计学上仍保持升高。
