Pomari C, Turco P, Trevisan F, Zoccatelli D, Dal Negro R W
Int J Clin Pharmacol Ther Toxicol. 1984 Sep;22(9):515-8.
A multiparametrical method was used in order to evaluate the characteristics of fog-challenge-induced bronchoreactivity. The effects of the bronchial stimulation were measured by means of spirometrical tests; determination of ventilatory resistances using a new method by interruption and rapid analysis of the expiratory gases, CO2 and He, according to the "multiple single breath" method. The protective efficacy of salbutamol and the salbutamol plus beclomethasone dipropionate combination was evaluated. The results obtained indicate that the combination exerts a greater protective effect, probably related to the stabilizing action of beclomethasone on the bronchial mucosa.
为评估雾激发诱导的支气管反应性特征，采用了多参数方法。通过肺量计测试来测量支气管刺激的效果；根据“多次单次呼吸”法，采用一种通过中断并快速分析呼气气体（二氧化碳和氦气）的新方法来测定通气阻力。评估了沙丁胺醇以及沙丁胺醇加二丙酸倍氯米松组合的保护效果。所获得的结果表明，该组合发挥了更大的保护作用，这可能与倍氯米松对支气管黏膜的稳定作用有关。
