Phillis J W, Preston G, DeLong R E
J Cereb Blood Flow Metab. 1984 Dec;4(4):586-92. doi: 10.1038/jcbfm.1984.83.
The purpose of these experiments was to determine the utility of a new method for monitoring CBF using a venous outflow technique with an extracorporeal circulation and to examine the effects of agents that potentiate or antagonize the actions of adenosine on the blood flow response to brief periods of anoxia. The results demonstrate the ability of the new technique to detect the increases in CBF in response to anoxia. Caffeine, an adenosine antagonist, reduced the intensity and duration of the anoxia-induced hyperemia. Dipyridamole and papaverine, inhibitors of adenosine uptake, potentiated the increase in CBF during anoxia. The results support the hypothesis that adenosine plays an important role in regulating CBF during anoxic episodes.
这些实验的目的是确定一种使用体外循环静脉流出技术监测脑血流量（CBF）的新方法的实用性，并研究增强或拮抗腺苷作用的药物对短暂缺氧期间血流反应的影响。结果表明新技术能够检测到缺氧引起的CBF增加。咖啡因是一种腺苷拮抗剂，可降低缺氧诱导的充血强度和持续时间。双嘧达莫和罂粟碱是腺苷摄取抑制剂，可增强缺氧期间CBF的增加。这些结果支持了腺苷在缺氧发作期间调节CBF中起重要作用的假说。
