Phillis J W, DeLong R E, Towner J K
Stroke. 1986 Mar-Apr;17(2):229-34. doi: 10.1161/01.str.17.2.229.
Cerebral blood flow (CBF) in the rat was monitored by a venous outflow technique with an extracorporeal circulation, which allows for the continuous recording of flow over periods of several hours. Brief periods of anoxia increase the rate of flow. The dihydropyridine calcium antagonists did not affect basal flow rate and depressed the increase in CBF elicited by anoxia. These findings may have significant implications for the therapeutic use of dihydropyridine calcium antagonists in brain ischaemia.
采用体外循环静脉流出技术监测大鼠脑血流量（CBF），该技术可连续记录数小时的血流量。短暂缺氧会增加血流量。二氢吡啶类钙拮抗剂不影响基础血流速率，并抑制缺氧引起的CBF增加。这些发现可能对二氢吡啶类钙拮抗剂在脑缺血治疗中的应用具有重要意义。
