血清中美西律的高压液相色谱测定法
High pressure liquid chromatographic assay for mexiletine in serum.
作者信息
Grech-Bélanger O, Turgeon J, Gilbert M
出版信息
J Chromatogr Sci. 1984 Nov;22(11):490-2. doi: 10.1093/chromsci/22.11.490.
PMID:6501531
Abstract
A highly sensitive, rapid, and specific high pressure liquid chromatographic assay for the analysis of the antiarrhythmic agent mexiletine is reported. The method involves extraction of mexiletine with organic solvent followed by analysis using fluorescence detection. The minimum measurable limit is 1 ng and inter- and intra-day coefficients of variation are less than 5.8%. The method is useful for pharmacokinetic studies and routine serum monitoring of mexiletine.
摘要
本文报道了一种用于分析抗心律失常药物美西律的高灵敏度、快速且特异的高效液相色谱法。该方法包括用有机溶剂萃取美西律，然后采用荧光检测进行分析。最低检测限为1纳克，日内和日间变异系数均小于5.8%。该方法可用于美西律的药代动力学研究和常规血清监测。
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