阿扑吗啡对慢性氟哌啶醇停药大鼠高香草酸的作用增强。
Increased effect of apomorphine on homovanillic acid in rats terminated from chronic haloperidol.
作者信息
Smith R C, Narasimhachari N, Davis J M
出版信息
J Neural Transm. 1978;42(2):159-62. doi: 10.1007/BF01675355.
PMID:650206
Abstract
Rats who were administered apomorphine seven days after termination of chronic treatment with haloperidol had significantly (59%) lower level of brain HVA than saline control rats. This finding is consistent with the behavioral evidence suggesting supersensitivity of post-synaptic dopamine receptors after termination of chronic haloperidol.
摘要
在停用氟哌啶醇慢性治疗七天后给予阿扑吗啡的大鼠，其脑内高香草酸（HVA）水平比生理盐水对照大鼠显著低（59%）。这一发现与行为学证据一致，表明慢性氟哌啶醇治疗终止后突触后多巴胺受体超敏。
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