Maier C E, McQuarrie I G, Singer M
J Exp Zool. 1984 Nov;232(2):181-6. doi: 10.1002/jez.1402320205.
A nerve-conditioning lesion induced sustained acceleration of limb regeneration. Newt limb nerves were subjected to a conditioning lesion by unilateral axotomy at the elbow 2 weeks prior to amputating both limbs above the elbows. Limbs on the side that had received a conditioning lesion began the regeneration process 3-4 days earlier than contralateral controls and this difference was observed up to recognizable digit formation. Limb buds on the conditioned sides had a twofold greater axonal density than contralateral counterparts at 2 weeks after amputation. Since limb bud formation is dependent on a sufficient quantity of axonal regrowth, accelerated limb regeneration is apparently due to accelerated reinnervation.
一种神经调节性损伤可诱导肢体再生持续加速。在肘部上方双侧截肢前2周，通过肘部单侧轴突切断术对蝾螈肢体神经进行调节性损伤。接受调节性损伤一侧的肢体比未接受损伤的对侧肢体早3 - 4天开始再生过程，这种差异一直持续到可识别的指（趾）形成阶段。截肢后2周时，接受调节性损伤一侧的肢体芽中的轴突密度比未接受损伤的对侧肢体芽中的轴突密度高两倍。由于肢体芽的形成依赖于足够数量的轴突再生，因此肢体再生加速显然是由于神经再支配加速所致。
