Koninckx C R, Giliams J P, Polanco I, Peña A S
J Pediatr Gastroenterol Nutr. 1984 Nov;3(5):676-82. doi: 10.1097/00005176-198411000-00006.
Antibodies against gliadin of the IgA class were assessed with an enzyme-linked immunosorbent assay technique in children with celiac disease, healthy blood donors, and adult patients with active Crohn's disease or ulcerative colitis. Significantly higher antibody values were found in celiac children during gluten challenge and during the first 3 months on a gluten-free diet, compared with the findings in the healthy blood donors. The patients with active Crohn's disease had significantly higher levels of IgA antibodies to gliadin than the controls did. Although the highest values were found in patients with celiac disease on a gluten-containing diet, the difference between the means of these two groups was not statistically significant. No correlation was found between disease activity in ulcerative colitis and antibody values. The present results support the view that high levels of IgA-class antibodies against gliadin are indicative of small intestinal disease, especially celiac disease. The variability of the levels of antibodies found among the patients suggests that not only the amount of gluten in the diet but also other factors are important.
采用酶联免疫吸附测定技术，对患有乳糜泻的儿童、健康献血者以及患有活动性克罗恩病或溃疡性结肠炎的成年患者，检测其抗麦醇溶蛋白IgA类抗体。与健康献血者相比，乳糜泻儿童在麸质激发试验期间以及无麸质饮食的头3个月中，抗体值显著更高。活动性克罗恩病患者的抗麦醇溶蛋白IgA抗体水平显著高于对照组。虽然含麸质饮食的乳糜泻患者抗体值最高，但这两组均值之间的差异无统计学意义。未发现溃疡性结肠炎的疾病活动与抗体值之间存在相关性。目前的结果支持以下观点：高水平的抗麦醇溶蛋白IgA类抗体表明存在小肠疾病，尤其是乳糜泻。患者之间抗体水平的变异性表明，不仅饮食中的麸质含量，其他因素也很重要。
