Forman M R, Meirik O, Berendes H W
JAMA. 1984 Dec 14;252(22):3135-9.
Using data from the Swedish Medical Birth Registry, we examined whether reproductive history influenced pregnancy outcomes among women aged 30 to 39 years who gave birth to a first or second child in 1976 through 1980. They were classified group 1, primigravida; group 2, gravida 2, para O; and group 3, gravida 2, para 1. Compared with women aged 20 through 24 years with the same parity and gravidity, the relative risk (RR) of late fetal deaths was significantly greater among those aged 35 through 39 years (RR: group 1 = 1.76, group 2 = 2.22, and group 3 = 2.39). The risk of giving birth to newborns who were low birth weight and preterm, or low birth weight at term, or 2,500 g or greater but preterm was greater among women aged 30 through 39 years in groups 1 and 2--significantly so for group 1 aged 30 through 39 years v group 1 aged 20 through 24 years. Risk increased with maternal age, from 30 through 34 to 35 through 39 years. The increased risk with age and parity-gravidity has ramifications for the increasing rate of delayed childbearing in the United States and elsewhere.
利用瑞典医学出生登记处的数据,我们研究了生育史是否会影响1976年至1980年间生育头胎或二胎的30至39岁女性的妊娠结局。她们被分为三组:第一组,初产妇;第二组,孕2产0;第三组,孕2产1。与年龄在20至24岁、具有相同胎次和妊娠次数的女性相比,35至39岁女性中晚期胎儿死亡的相对风险(RR)显著更高(RR:第一组 = 1.76,第二组 = 2.22,第三组 = 2.39)。在第一组和第二组中,年龄在30至39岁的女性生出低体重儿、早产儿,或足月低体重儿,或体重2500克及以上但为早产儿的风险更高——对于年龄在30至39岁的第一组女性与年龄在20至24岁的第一组女性相比,情况尤为显著。风险随着母亲年龄的增加而增加,从30至34岁到35至39岁。年龄和胎次-妊娠次数增加带来的风险增加对美国及其他地区生育延迟率的上升具有影响。