Erichsen C, Jönsson P E
J Surg Oncol. 1984 Dec;27(4):268-70. doi: 10.1002/jso.2930270415.
A case of veno-occlusive disease of the liver with fatal outcome after dacarbazine (DTIC) therapy for melanoma is reported. There was a fulminant clinical course from start of symptoms until death. At autopsy the liver was enlarged and firm with signs of venous congestion. Small- and medium-sized hepatic veins were blocked by thrombosis. Eosinophilic infiltrations were found around the vessels. Published cases from the literature are reviewed and pertinent features discussed.
报告了1例黑色素瘤患者在接受达卡巴嗪（DTIC）治疗后发生肝静脉闭塞性疾病并导致死亡的病例。从症状开始出现到死亡，临床过程呈暴发性。尸检时肝脏肿大且质地坚硬，有静脉充血迹象。中小肝静脉被血栓阻塞。在血管周围发现嗜酸性粒细胞浸润。对文献中已发表的病例进行了综述，并讨论了相关特征。
