Kinoshita H
Nihon Geka Gakkai Zasshi. 1984 Sep;85(9):1138-42.
Of the 1,396 patients who underwent gastroenterological surgery at our department in the past seven years, 132 (9.5%) developed surgical wound infections. The incidence of such infections varied greatly depending on the location and method of the operation. The causative organisms isolated from these infections were often the same as the normal bacterial flora in the organ that was the object of the surgery. Frequent factors of intra-abdominal infection, of which there were 62 cases, were leakage and intra-abdominal bleeding after extended operations in a compromised host. Antibiotics are not substitutes for careful surgical technique. For Escherichia coli and Klebsiella isolated from clinical specimens, we found that the antibiotics Cephalothin and Cefazolin did have satisfactory antibacterial activity. The first and second generation cephems seem suitable for use as prophylactic antibiotics against surgical wound infection. The best time to start giving prophylactic antibiotics was during the operation. Useful indicators of postoperative infection are the fever index, leucocytosis, CRP, and the erythrocyte sedimentation rate.
在过去七年中，我院胃肠外科实施手术的1396例患者中，有132例（9.5%）发生了手术切口感染。此类感染的发生率因手术部位和方式的不同而有很大差异。从这些感染中分离出的病原菌通常与手术器官中的正常菌群相同。腹腔内感染常见因素（共62例）为宿主功能受损情况下扩大手术后的渗漏和腹腔内出血。抗生素不能替代精细的手术操作。对于从临床标本中分离出的大肠杆菌和克雷伯菌，我们发现头孢噻吩和头孢唑林这两种抗生素确实具有令人满意的抗菌活性。第一代和第二代头孢菌素似乎适合用作预防手术切口感染的抗生素。开始使用预防性抗生素的最佳时间是在手术期间。术后感染的有用指标是发热指数、白细胞增多、C反应蛋白和红细胞沉降率。
