Kolesnichenko T S, Antoshina E E, Medvinskiĭ A L
Ontogenez. 1984 Sep-Oct;15(5):522-8.
Methods of separation of the mouse embryonic lung mesenchyme (M) and epithelium (E) and obtaining homolinear and heterolinear organotypic aggregates of E and M from the intact and urethane-treated (transplacentally) A and C57BL mouse embryos. In the aggregates formed by E and M from the experimental A embryos, the index of labelled nuclei (3H-thymidine incorporation) in both the tissue components was several times that in the aggregates of E and M from the intact embryos. M from the experimental embryos aggregated with E from the intact embryos increased the proliferative activity of the latter 4 to 11 times, whereas M of the intact embryos aggregated with E of the experimental embryos decreased its proliferative activity to the normal level. A suggestion is put forward that the embryonic lung mesenchyme plays an important role in the realization of transplacental carcinogenic influences and in the development of lung epithelial tumours.
从小鼠胚胎肺中分离间充质（M）和上皮（E）的方法，以及从完整的和经氨基甲酸乙酯处理（经胎盘）的A系和C57BL系小鼠胚胎中获得E和M的同线性和异线性器官型聚集体的方法。在由实验性A系胚胎的E和M形成的聚集体中，两种组织成分中标记细胞核的指数（3H-胸腺嘧啶核苷掺入）是完整胚胎的E和M聚集体中的几倍。实验性胚胎的M与完整胚胎的E聚集，使后者的增殖活性提高了4至11倍，而完整胚胎的M与实验性胚胎的E聚集，则使其增殖活性降至正常水平。有人提出，胚胎肺间充质在经胎盘致癌影响的实现以及肺上皮肿瘤的发生发展中起重要作用。
