致癌物乙酰氨基芴的C8-取代鸟嘌呤加合物的构象与动力学研究；一种可能的Z-DNA修饰结构模型。
Studies on the conformation and dynamics of the C8-substituted guanine adduct of the carcinogen acetylaminofluorene; model for a possible Z-DNA modified structure.
作者信息
Neidle S, Kuroda R, Broyde S, Hingerty B E, Levine R A, Miller D W, Evans F E
出版信息
Nucleic Acids Res. 1984 Nov 12;12(21):8219-33. doi: 10.1093/nar/12.21.8219.
Abstract
The structure of an adduct between guanine and the carcinogen acetylaminofluorene has been examined in the solid state by X-ray crystallography, and in solution by NMR techniques. The observed conformations have been compared with predictions from energy calculations and their relevance to models of adducts with DNA has been examined.
摘要
鸟嘌呤与致癌物乙酰氨基芴加合物的结构已通过X射线晶体学在固态下进行了研究，并通过核磁共振技术在溶液中进行了研究。已将观察到的构象与能量计算的预测结果进行了比较，并研究了它们与DNA加合物模型的相关性。
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