Micanovic R, Kruggel W, Ray P, Lewis R V
Peptides. 1984 Sep-Oct;5(5):853-6. doi: 10.1016/0196-9781(84)90105-0.
A non-enkephalin containing pentadeca peptide derived from ovine adrenal proenkephalin has been purified and sequenced. The sequence of the peptide is: Phe-Ala-Glu-Pro-Leu-Pro-Ser-Glu-Glu-Glu-Gly-Glu-Ser-Tyr-Ser (preproenkephalin 237-251) representing the amino portion of peptide B (preproenkephalin 237-268). The sequence is identical to bovine preproenkephalin 237-251, differing from the corresponding human sequence at positions 240 and 244. This peptide can be generated by a processing event common to other opioid peptides and is present in chromaffin granules in significant amounts. The presence of this peptide in substantial quantities suggests a possible difference in proenkephalin processing between the bovine and ovine adrenal medulla.
一种源自绵羊肾上腺前脑啡肽原的不含脑啡肽的十五肽已被纯化并测序。该肽的序列为：苯丙氨酸-丙氨酸-谷氨酸-脯氨酸-亮氨酸-脯氨酸-丝氨酸-谷氨酸-谷氨酸-谷氨酸-甘氨酸-谷氨酸-丝氨酸-酪氨酸-丝氨酸（前脑啡肽原237-251），代表肽B（前脑啡肽原237-268）的氨基部分。该序列与牛前脑啡肽原237-251相同，在第240位和244位与相应的人类序列不同。这种肽可通过其他阿片肽共有的加工过程产生，并且大量存在于嗜铬颗粒中。该肽大量存在表明牛和绵羊肾上腺髓质在前脑啡肽原加工方面可能存在差异。
