Paré W P, Vincent G P
Physiol Behav. 1984 Aug;33(2):305-8. doi: 10.1016/0031-9384(84)90117-3.
Male Sprague-Dawley rats, 2, 6, 11, 18, and 26 months old, were subdivided into four drug treatment groups and received either 25, 50, 100 mg/kg of cimetidine or a placebo control before being exposed to restraint plus cold stress for 3 hr. Cimetidine, at all dose levels, significantly reduced ulcer severity in all age groups except the 18- and 26-month-old rats. Senescent rats were not more susceptible to restraint ulcer and cimetidine had the least anti-ulcer effect with the senescent 26-month-old rats.
将2、6、11、18和26月龄的雄性斯普拉格-道利大鼠分为四个药物治疗组，在接受3小时的束缚加冷应激之前，分别给予25、50、100mg/kg的西咪替丁或安慰剂对照。在所有剂量水平下，西咪替丁均能显著降低除18和26月龄大鼠外所有年龄组的溃疡严重程度。衰老大鼠对束缚性溃疡并不更敏感，且西咪替丁对26月龄衰老大鼠的抗溃疡作用最小。
