Michalowski A
Radiother Oncol. 1984 Jan;1(3):241-6. doi: 10.1016/s0167-8140(84)80006-7.
Assessment of radiation damage to normal tissues in terms of dose-response curves for infinite proliferative potential ("survival curves") does not take into account the decrease with increasing dose of the multiplication rate of the clonogenic and non-clonogenic (radiation-sterilized) cells which may be implicated in the expression of the damage to tissue function or gross appearance. While radiation selectively lowers the chance of successful mitotic divisions, other anticancer agents may in addition interfere with different cellular processes. Comparisons of effectiveness of radiation with that of other modalities should not therefore be limited to analysis of survival curves. Assays of cell "survival" in self-renewing normal tissues in situ often define properties of a non-random sample of the clonogens. The nature of repair associated with the post-irradiation delay in performance of transplantation assays for normal clonogenic cells remains unclear. Dose-response relationships for functional impairment or gross damage to tissue, especially those obtained by irradiation with many fractions, do not necessarily yield to interpretation in terms of clonogenic cell "survival".
根据无限增殖潜能的剂量反应曲线（“存活曲线”）来评估正常组织的辐射损伤，没有考虑到随着剂量增加，克隆形成细胞和非克隆形成细胞（辐射灭活细胞）的增殖率会下降，而这些细胞可能与组织功能损伤或外观改变的表现有关。虽然辐射会选择性地降低成功进行有丝分裂的几率，但其他抗癌药物可能还会干扰不同的细胞过程。因此，将辐射与其他治疗方式的有效性进行比较时，不应局限于对存活曲线的分析。原位自我更新的正常组织中细胞“存活”的检测通常定义了克隆原细胞非随机样本的特性。对于正常克隆形成细胞，移植检测的性能在照射后延迟与修复的性质仍不清楚。组织功能损伤或总体损伤的剂量反应关系，尤其是通过多次分割照射获得的关系，不一定能根据克隆形成细胞“存活”来解释。
